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KMID : 1161920170140010023
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Journal of Medicine and Life Science
2017 Volume.14 No. 1 p.23 ~ p.28
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Effect of Supplementation of Jeju Magma Seawater on Glucose Transport in Cultured L6 Skeletal Muscle Cells
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Ma Gun-Jung
Kim Soo-Jung
Park Deok-Bae
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Abstract
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Magma seawater, the underground seawater in Jeju island, contains abundant minerals. Previous studies have suggested the beneficial effect of deep seawater on hyperlipidemia and cardiovascular diseases. We investigated the in vitro effect of magma seawater on the glucose transport by skeletal muscle cells, a key regulatory mechanism to maintain blood glucose levels. Stepwise supplementation of magma seawater (898-1,898 of hardness) to the cell culture mdieum did not affect the viability of L6 myoblasts. In differentiated L6 skeletal muscle cells, the supplementation of magma seawater elevated the basal- and insulin-induced glucose transport into cells. Akt and AMPK, insulin-dependent and ?independent signaling pathways to lead glucose transport respectively, were stimulated by the supplementation of magma seawater to the culture medium. Taken together, magma seawater of Jeju has a physiological potential to maintain body glucose homeostasis.
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KEYWORD
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Magma seawater, glucose transport, skeletal muscle cells
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